Epidermis morphogenesis

Across TCGA patient cohorts, RNA activity of the Epidermis morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, GSN, and PDLIM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epidermis morphogenesis activity versus COL3A1 in OV (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL3A1 →	+0.693	+0.044	<.001	.001	3	6
PDAC	GSN →	+0.777	+0.061	<.001	<.001	3	6
COAD	PDLIM4 →	+0.652	+0.039	<.001	<.001	3	6
LSCC	UBE2J1_S251 →	-0.820	-0.075	<.001	<.001	3	6
OV	CNPY4 →	+0.350	+0.042	<.001	<.001	3	6
OV	FSTL1 →	+0.664	+0.045	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048730 vs COL3A1 — OV

Explore this scatter interactively →