Epidermis morphogenesis

Across TCGA patient cohorts, RNA activity of the Epidermis morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT17, PERP, and SEPTIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epidermis morphogenesis activity versus KRT17 in LSCC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT17 →	+2.550	+0.867	<.001	<.001	3	6
LSCC	PERP →	+1.453	+1.233	<.001	<.001	3	6
BRCA	SEPTIN1 →	-0.835	-0.876	<.001	<.001	3	5
LSCC	KRT6A →	+2.680	+0.741	<.001	<.001	3	5
HNSC	CD74 →	-0.841	-0.608	.001	<.001	3	5
LSCC	SEPTIN10 →	+0.521	+0.681	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048730 vs KRT17 — LSCC

Explore this scatter interactively →