Epidermis morphogenesis

Across TCGA cell cohorts, RNA activity of the Epidermis morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT17, C10orf88, and CACNA1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epidermis morphogenesis activity versus KRT17 in STOMACH (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KRT17 →	+6.078	+2.089	<.001	<.001	3	6
BONE	C10orf88 →	-0.825	-1.774	.002	<.001	3	3
BONE	CACNA1C →	-3.050	-1.884	.002	<.001	3	3
SOFT_TISSUE	ZNF559 →	-1.326	-1.615	.002	<.001	3	3
LARGE_INTESTINE	PLVAP →	+0.031	+1.060	.008	.005	3	3
PANCREAS	SUPT6H →	-0.645	-1.401	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048730 vs KRT17 — STOMACH

Explore this scatter interactively →