Negative regulation of oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of oligodendrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3H, VCL_S346, and TNS2_S102, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oligodendrocyte differentiation activity versus EIF3H in HNSC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EIF3H →	-0.157	-0.070	<.001	<.001	3	7
BRCA	VCL_S346 →	+0.495	+0.048	.002	<.001	3	7
LUAD	TNS2_S102 →	+0.500	+0.067	.001	<.001	3	7
GBM	SEPTIN4_S432 →	+0.979	+0.103	<.001	<.001	3	7
OV	DCN →	+0.655	+0.052	.001	.001	3	6
OV	GUCY1A1 →	+0.434	+0.058	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048715 vs EIF3H — HNSC

Explore this scatter interactively →