Negative regulation of oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAG3, EXOSC3P1, and RPL17P15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oligodendrocyte differentiation activity versus LAG3 in UCEC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAG3 →	-0.603	-0.209	<.001	<.001	3	5
HNSC	EXOSC3P1 →	+0.591	+0.240	.003	.008	3	4
HNSC	RPL17P15 →	+0.866	+0.374	<.001	<.001	3	4
PDAC	AKR1C6P →	+0.568	+0.594	<.001	.001	3	3
UCEC	PTPRU →	+0.688	+0.184	<.001	<.001	3	3
GBM	LRP4-AS1 →	+0.610	+0.285	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048715 vs LAG3 — UCEC

Explore this scatter interactively →