Negative regulation of oligodendrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNIP, SMG6, and DEPTOR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXNIP grouped by Negative regulation of oligodendrocyte differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TXNIP →	+2.927	+1.223	<.001	<.001	3	5
SKIN	SMG6 →	+0.602	+1.150	.007	<.001	3	5
BLOOD_Myeloma	DEPTOR →	-2.963	-1.493	.001	<.001	3	4
SKIN	ZSCAN5A →	-0.953	-1.217	<.001	<.001	3	4
STOMACH	MDM1 →	+0.625	+1.367	.001	.001	3	4
LIVER	ALDH1A3 →	+2.369	+1.070	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXNIP by Negative regulation of oligodendrocyte differentiation activity — OESOPHAGUS

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