Positive regulation of oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL34, IL33, and TAF5LP1, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oligodendrocyte differentiation activity versus IL34 in CHOL (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	IL34 →	+2.132	+0.068	<.001	<.001	2	24
SKCM	IL33 →	+1.269	+0.036	<.001	<.001	3	21
SKCM	TAF5LP1 →	+0.819	+0.031	<.001	<.001	3	20
LAML	CIITA →	+1.253	+0.062	<.001	<.001	3	20
KIRC	MS4A4E →	+0.600	+0.038	<.001	<.001	3	20
UCS	STAB1 →	+1.382	+0.059	<.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048714 vs IL34 — CHOL

Explore this scatter interactively →