Positive regulation of oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of oligodendrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL33, SH3BP1, and SELL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oligodendrocyte differentiation activity versus IL33 in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IL33 →	+0.815	+0.075	<.001	<.001	3	6
BRCA	SH3BP1 →	+0.187	+0.031	<.001	.007	3	6
BRCA	SELL →	+0.451	+0.049	<.001	<.001	3	5
HNSC	BIN1 →	+0.735	+0.055	<.001	.001	3	5
GBM	PIP4K2A →	+0.496	+0.075	.005	<.001	3	5
OV	RNMT →	-0.254	-0.045	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048714 vs IL33 — PDAC

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