Regulation of oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORA38B, UBL5P2, and IDSP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oligodendrocyte differentiation activity versus SNORA38B in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNORA38B →	+0.783	+0.168	.003	.009	3	3
UCEC	UBL5P2 →	+0.766	+0.120	.004	.005	3	3
LUAD	IDSP1 →	+0.460	+0.087	<.001	.001	3	3
BRCA	RNU6-529P →	+0.483	+0.109	.003	.006	3	3
BRCA	UBE2D3-AS1 →	+0.450	+0.147	.001	.008	3	3
PDAC	MRPL30 →	-0.187	-0.233	.004	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048713 vs SNORA38B — HNSC

Explore this scatter interactively →