Regulation of astrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, PDE1B, and SKA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of astrocyte differentiation activity versus CNRIP1 in GBM (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CNRIP1 →	+0.743	+0.442	<.001	.007	3	4
BRCA	PDE1B →	+0.385	+0.534	<.001	<.001	3	4
BRCA	SKA1 →	-0.798	-0.597	.003	.007	3	4
BRCA	EFEMP2 →	+0.544	+0.553	.004	<.001	3	4
BRCA	RPL9P2 →	+0.454	+0.569	<.001	.004	3	4
GBM	TMEM72-AS1 →	+0.435	+0.435	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048710 vs CNRIP1 — GBM

Explore this scatter interactively →