Oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XPC-AS1, NBPF12, and DLEU2L, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligodendrocyte differentiation activity versus XPC-AS1 in KIRP (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	XPC-AS1 →	+0.567	+0.026	<.001	<.001	3	25
THYM	NBPF12 →	+0.657	+0.025	<.001	<.001	3	25
SARC	DLEU2L →	+0.438	+0.015	<.001	<.001	3	24
TGCT	AGO3 →	+0.725	+0.041	<.001	<.001	3	24
THYM	TSSK4 →	+0.752	+0.023	<.001	<.001	3	24
TGCT	ARMCX4 →	+1.130	+0.041	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048709 vs XPC-AS1 — KIRP

Explore this scatter interactively →