Oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Oligodendrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCHE, FERMT3, and NCALD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligodendrocyte differentiation activity versus BCHE in BRCA (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BCHE →	+0.690	+0.033	<.001	<.001	3	6
PDAC	FERMT3 →	-0.365	-0.029	.001	<.001	3	5
LUAD	NCALD →	+0.442	+0.028	.004	.002	3	5
HNSC	STK10 →	-0.304	-0.050	.001	.007	3	5
GBM	FRYL →	-0.218	-0.063	<.001	.001	3	5
LSCC	MLKL →	-0.334	-0.020	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048709 vs BCHE — BRCA

Explore this scatter interactively →