Oligodendrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Oligodendrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC11B, GAB1, and CILK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligodendrocyte differentiation activity versus ZDHHC11B in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZDHHC11B →	+1.276	+0.317	.004	.005	3	5
BRCA	GAB1 →	+0.500	+0.207	.007	.005	3	4
HNSC	CILK1 →	+0.787	+0.132	.001	.004	3	4
HNSC	DLG1 →	+0.422	+0.129	.002	<.001	3	4
BRCA	ERMP1 →	+0.716	+0.268	.002	<.001	3	4
LSCC	GCLC →	+1.194	+0.158	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048709 vs ZDHHC11B — GBM

Explore this scatter interactively →