Oligodendrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Oligodendrocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B2, MTOR, and CHRAC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2B2 grouped by Oligodendrocyte differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EIF2B2 →	-0.375	-0.119	<.001	<.001	3	5
BREAST	MTOR →	-0.326	-0.123	.002	.001	3	5
PANCREAS	CHRAC1 →	-0.185	-0.193	.001	<.001	3	5
OVARY	BTF3L4 →	+0.351	+0.208	.001	.002	3	4
OESOPHAGUS	OR7G2 →	+0.244	+0.201	.008	.005	3	4
URINARY_TRACT	LRRC32 →	-0.155	-0.209	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2B2 by Oligodendrocyte differentiation activity — BREAST

Explore this box plot interactively →