Astrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, CD93, and COL6A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte differentiation activity versus SPARC in OV (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPARC →	+1.689	+0.324	<.001	<.001	3	8
OV	CD93 →	+1.136	+0.328	<.001	<.001	3	8
OV	COL6A1 →	+1.802	+0.313	<.001	<.001	3	8
BRCA	MEG3 →	+1.088	+0.205	<.001	<.001	3	8
UCEC	VIM →	+1.064	+0.204	.001	.001	3	8
BRCA	MEIS3 →	+1.171	+0.234	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048708 vs SPARC — OV

Explore this scatter interactively →