Astrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP32, RAPGEF5, and TBX6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP32 grouped by Astrocyte differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARHGAP32 →	+1.831	+0.269	.004	.001	2	5
OVARY	RAPGEF5 →	+0.770	+1.040	.005	.002	3	4
KIDNEY	TBX6 →	-0.423	-0.739	.004	.008	3	3
LUNG_NSCLC_LUAD	PLEKHA2 →	-1.135	-0.586	.007	.009	3	3
KIDNEY	CEP152 →	-0.918	-1.214	.003	.003	3	2
KIDNEY	WNT9A →	+0.829	+0.940	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP32 by Astrocyte differentiation activity — STOMACH

Explore this box plot interactively →