Astrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Astrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD14A, CDKL3, and IFNAR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte differentiation activity versus ABHD14A in KIDNEY (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ABHD14A →	-1.736	-1.425	<.001	.005	3	5
BONE	CDKL3 →	+1.266	+1.350	<.001	.005	3	4
SKIN	IFNAR2 →	+0.683	+1.361	.004	<.001	3	4
SKIN	CTSO →	+1.554	+1.260	.004	<.001	3	4
SKIN	DGAT2 →	+1.645	+1.171	<.001	<.001	3	4
OVARY	MRPS22 →	-0.675	-0.869	.008	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048708 vs ABHD14A — KIDNEY

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