Skeletal system morphogenesis

Across TCGA patient cohorts, RNA activity of the Skeletal system morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, ISLR, and VCL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal system morphogenesis activity versus VCAN in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VCAN →	+1.087	+0.041	<.001	<.001	3	9
BRCA	ISLR →	+0.847	+0.035	<.001	<.001	3	9
UCEC	VCL →	+0.515	+0.031	<.001	.001	3	9
BRCA	TLN2 →	+0.731	+0.036	<.001	<.001	3	9
LSCC	DDX21_S89 →	-0.940	-0.037	<.001	<.001	3	9
BRCA	SERPINF1 →	+1.007	+0.032	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048705 vs VCAN — LSCC

Explore this scatter interactively →