Skeletal system morphogenesis

Across TCGA cell cohorts, RNA activity of the Skeletal system morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAFAH1B2, ASPHD1, and WDR35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal system morphogenesis activity versus PAFAH1B2 in OESOPHAGUS (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PAFAH1B2 →	-0.668	-0.218	<.001	.003	3	5
OESOPHAGUS	ASPHD1 →	-1.875	-0.274	.005	.001	3	5
STOMACH	WDR35 →	-1.767	-0.411	.008	.005	3	5
SKIN	UHRF1BP1L →	-0.516	-0.284	.002	.004	3	5
BREAST	CAMLG →	-0.925	-0.271	<.001	<.001	3	5
OVARY	ADGRE5 →	-1.783	-0.246	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048705 vs PAFAH1B2 — OESOPHAGUS

Explore this scatter interactively →