Axon extension

Across TCGA patient cohorts, RNA activity of the Axon extension pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, NOLC1_S538, and CCN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon extension activity versus MAP1B in LSCC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+0.859	+0.041	<.001	<.001	3	7
BRCA	NOLC1_S538 →	-0.710	-0.032	<.001	<.001	3	7
BRCA	CCN2 →	+0.549	+0.024	.006	<.001	3	7
OV	SERBP1 →	-0.301	-0.041	.002	.001	3	6
OV	TIMP2 →	+0.539	+0.045	.003	.001	2	7
OV	VCAN →	+1.177	+0.044	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048675 vs MAP1B — LSCC

Explore this scatter interactively →