Axon extension

Across TCGA patient cohorts, RNA activity of the Axon extension pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, STAC, and DOK5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon extension activity versus INHBA in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	INHBA →	+1.381	+0.314	<.001	<.001	3	4
BRCA	STAC →	+1.205	+0.238	<.001	<.001	3	3
BRCA	DOK5 →	+0.892	+0.194	<.001	<.001	3	3
BRCA	ACTA2 →	+1.169	+0.188	<.001	<.001	3	3
CCRCC	PMP22 →	+0.852	+0.250	.004	.001	3	3
CCRCC	WNT5B →	+0.792	+0.218	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048675 vs INHBA — BRCA

Explore this scatter interactively →