Axon extension

Across TCGA cell cohorts, RNA activity of the Axon extension pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS2, ACADS, and TTC13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARS2 grouped by Axon extension-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MARS2 →	+0.832	+1.855	.005	<.001	2	5
BLOOD_Myeloma	ACADS →	+1.100	+1.512	.002	<.001	3	4
LIVER	TTC13 →	-0.894	-1.436	<.001	<.001	3	4
LARGE_INTESTINE	PRR3 →	+1.032	+1.007	.003	.004	3	4
PANCREAS	ACIN1 →	+0.754	+1.349	<.001	.001	3	3
PANCREAS	ADGRE5 →	-0.802	-1.155	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARS2 by Axon extension activity — BLOOD_Lymphoma

Explore this box plot interactively →