Axon extension

Across TCGA cell cohorts, RNA activity of the Axon extension pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YPEL5, GDI1, and SEMA3A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon extension activity versus YPEL5 in LUNG_NSCLC_LUSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	YPEL5 →	+1.257	+0.087	<.001	.002	3	9
LIVER	GDI1 →	+1.145	+0.124	<.001	<.001	2	9
PANCREAS	SEMA3A →	+2.620	+0.115	<.001	<.001	3	8
LARGE_INTESTINE	PRR5 →	-1.042	-0.077	.001	<.001	3	8
STOMACH	ALCAM →	+3.681	+0.107	<.001	<.001	3	8
SKIN	GLIPR1 →	+2.179	+0.063	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048675 vs YPEL5 — LUNG_NSCLC_LUSC

Explore this scatter interactively →