Axon extension

Across TCGA cell cohorts, RNA activity of the Axon extension pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALCAM, KLF7, and BAG3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon extension activity versus ALCAM in SOFT_TISSUE (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ALCAM →	+3.308	+1.687	<.001	<.001	3	5
SOFT_TISSUE	KLF7 →	+2.162	+1.775	.007	.001	3	5
SOFT_TISSUE	BAG3 →	+1.467	+2.138	.003	<.001	2	6
SOFT_TISSUE	CTSB →	+2.007	+1.787	<.001	<.001	3	5
LUNG_NSCLC_LUSC	GPR176 →	+3.655	+1.718	.002	<.001	3	5
SOFT_TISSUE	SLC25A33 →	-1.397	-1.787	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048675 vs ALCAM — SOFT_TISSUE

Explore this scatter interactively →