Positive regulation of collateral sprouting

Across TCGA patient cohorts, RNA activity of the Positive regulation of collateral sprouting pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRABP2, NUP93, and BTD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of collateral sprouting activity versus CRABP2 in LUAD (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CRABP2 →	+0.909	+0.050	<.001	.004	2	7
BRCA	NUP93 →	+0.153	+0.038	.003	.009	3	5
BRCA	BTD →	-0.378	-0.037	<.001	.001	3	5
BRCA	TNS2 →	-0.316	-0.043	<.001	<.001	3	4
BRCA	DCAF8_S129 →	-0.526	-0.150	.003	.005	3	4
BRCA	EHD2_S468 →	-0.758	-0.065	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048672 vs CRABP2 — LUAD

Explore this scatter interactively →