Positive regulation of collateral sprouting

Across TCGA patient cohorts, RNA activity of the Positive regulation of collateral sprouting pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP5, GRK3, and CYP4X1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of collateral sprouting activity versus AKAP5 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKAP5 →	+0.616	+0.225	.001	.007	2	5
COAD	GRK3 →	+0.345	+0.413	.005	.007	3	3
BRCA	CYP4X1 →	+1.648	+0.187	.003	.008	3	3
GBM	KCNJ10 →	+0.795	+0.172	.001	.002	3	3
LSCC	SEMA4D →	+0.363	+0.152	<.001	<.001	3	3
GBM	LINC01845 →	+0.387	+0.210	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048672 vs AKAP5 — BRCA

Explore this scatter interactively →