Negative regulation of collateral sprouting

Across TCGA patient cohorts, RNA activity of the Negative regulation of collateral sprouting pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL2_S1381, PLOD1, and BCAS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of collateral sprouting activity versus CARMIL2_S1381 in OV (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CARMIL2_S1381 →	-1.920	-0.075	.001	<.001	3	7
HNSC	PLOD1 →	+0.437	+0.059	<.001	.002	3	6
BRCA	BCAS1 →	-1.127	-0.043	<.001	<.001	3	6
BRCA	BLNK →	-0.346	-0.044	<.001	<.001	3	6
PDAC	PLOD2 →	+0.462	+0.046	.001	<.001	3	6
BRCA	RBM34 →	+0.508	+0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048671 vs CARMIL2_S1381 — OV

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