Negative regulation of collateral sprouting

Across TCGA patient cohorts, RNA activity of the Negative regulation of collateral sprouting pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, CLEC5A, and TREM1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of collateral sprouting activity versus SPP1 in BRCA (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPP1 →	+1.743	+0.933	<.001	<.001	3	10
PDAC	CLEC5A →	+0.858	+0.649	<.001	.003	3	8
GBM	TREM1 →	+1.046	+0.363	.002	.001	3	7
BRCA	LINC01705 →	+0.617	+0.597	<.001	.001	3	7
LSCC	P4HA2 →	+0.470	+1.150	<.001	<.001	3	7
LUAD	LHFPL2 →	+0.427	+0.825	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048671 vs SPP1 — BRCA

Explore this scatter interactively →