Negative regulation of collateral sprouting

Across TCGA cell cohorts, RNA activity of the Negative regulation of collateral sprouting pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NISCH, HERC1, and TTC23, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of collateral sprouting activity versus NISCH in LUNG_SCLC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NISCH →	+0.822	+0.522	<.001	.006	3	1
LUNG_SCLC	HERC1 →	+0.714	+0.522	<.001	.006	3	1
LUNG_SCLC	TTC23 →	+1.511	+0.522	.002	.006	3	1
LUNG_SCLC	HOMER2 →	+1.471	+0.522	.007	.006	3	1
LUNG_SCLC	DMXL2 →	+1.363	+0.356	.004	.004	3	1
LUNG_SCLC	BLOC1S6 →	+0.887	+0.522	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048671 vs NISCH — LUNG_SCLC

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