Regulation of collateral sprouting

Across TCGA cell cohorts, RNA activity of the Regulation of collateral sprouting pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM214B, BCS1L, and DTX3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM214B grouped by Regulation of collateral sprouting-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM214B →	-0.986	-1.182	.005	<.001	3	4
CNS	BCS1L →	+0.391	+0.719	.007	.006	3	4
LIVER	DTX3 →	-2.800	-1.505	.002	.005	3	4
BLOOD_Leukemia	NARS2 →	+0.630	+0.973	.002	.001	3	4
STOMACH	UQCC3 →	+0.660	+1.284	.005	.001	3	4
OESOPHAGUS	NDUFA1 →	-1.056	-1.034	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM214B by Regulation of collateral sprouting activity — CNS

Explore this box plot interactively →