Collateral sprouting

Across TCGA patient cohorts, RNA activity of the Collateral sprouting pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ULK2, EZH1, and CPLANE1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collateral sprouting activity versus ULK2 in SCLC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ULK2 →	+1.000	+0.121	<.001	<.001	2	29
SARC	EZH1 →	+0.727	+0.033	<.001	<.001	3	26
ESCA	CPLANE1 →	+0.899	+0.063	<.001	<.001	3	26
THYM	UBE2Q2P1 →	+0.815	+0.060	<.001	<.001	3	26
THYM	ZNF532 →	+1.372	+0.058	<.001	<.001	3	26
UCS	PIGCP1 →	+1.041	+0.048	.002	.006	2	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048668 vs ULK2 — SCLC

Explore this scatter interactively →