Collateral sprouting

Across TCGA patient cohorts, RNA activity of the Collateral sprouting pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNAJC1, DENND2D, and DLD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collateral sprouting activity versus DNAJC1 in BRCA (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNAJC1 →	-0.529	-0.029	.001	.002	3	5
BRCA	DENND2D →	-0.424	-0.025	<.001	.005	3	5
LSCC	DLD →	+0.288	+0.027	<.001	.006	3	5
BRCA	RHEB →	+0.268	+0.026	<.001	<.001	3	4
BRCA	ATG4B →	+0.277	+0.034	<.001	<.001	3	4
OV	SET_S7 →	-0.712	-0.050	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048668 vs DNAJC1 — BRCA

Explore this scatter interactively →