Collateral sprouting

Across TCGA patient cohorts, RNA activity of the Collateral sprouting pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPP1, SPP1_S195, and SPP1_S234, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collateral sprouting activity versus SPP1 in BRCA (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPP1 →	+1.181	+1.046	<.001	<.001	3	9
LSCC	SPP1_S195 →	+1.625	+1.283	<.001	<.001	3	8
LSCC	SPP1_S234 →	+1.881	+1.202	<.001	<.001	3	8
UCEC	SPP1_S263 →	+1.507	+1.028	<.001	<.001	3	7
LSCC	SPP1_S311 →	+1.689	+1.100	<.001	<.001	3	7
LUAD	SPP1_S62 →	+1.677	+1.069	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048668 vs SPP1 — BRCA

Explore this scatter interactively →