Neuron fate specification

Across TCGA patient cohorts, RNA activity of the Neuron fate specification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1, FYB1, and LCP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron fate specification activity versus FMNL1 in GBM (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FMNL1 →	-0.383	-0.053	<.001	<.001	3	6
GBM	FYB1 →	-0.607	-0.075	.003	<.001	3	6
GBM	LCP2 →	-0.508	-0.096	<.001	<.001	3	6
UCEC	RCSD1_S351 →	-0.453	-0.071	.003	.004	3	5
GBM	FCER1G →	-0.690	-0.076	.003	<.001	3	5
GBM	ARPC4 →	-0.256	-0.072	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048665 vs FMNL1 — GBM

Explore this scatter interactively →