Neuron fate specification

Across TCGA patient cohorts, RNA activity of the Neuron fate specification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD6, ZNF442, and NFIA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron fate specification activity versus CHD6 in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHD6 →	+0.698	+0.599	<.001	<.001	3	6
BRCA	ZNF442 →	+0.462	+0.540	<.001	.005	3	6
GBM	NFIA →	+0.566	+0.477	<.001	<.001	3	6
UCEC	ING4 →	+0.611	+0.500	.002	<.001	3	5
BRCA	METTL25 →	+0.489	+0.510	<.001	.002	3	5
UCEC	NUMA1 →	+0.730	+0.560	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048665 vs CHD6 — BRCA

Explore this scatter interactively →