Neuron fate specification

Across TCGA cell cohorts, RNA activity of the Neuron fate specification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLUAP1, SMC3, and PEX10, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron fate specification activity versus CLUAP1 in BLOOD_Lymphoma (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CLUAP1 →	+1.319	+1.694	.002	.008	3	2
BLOOD_Lymphoma	SMC3 →	+1.235	+1.928	.006	.003	3	2
BLOOD_Lymphoma	PEX10 →	+1.384	+1.897	.006	.005	3	2
BLOOD_Lymphoma	ARL15 →	+2.325	+1.928	.003	.003	3	2
BLOOD_Lymphoma	CHUK →	+1.025	+1.928	.004	.003	3	2
LUNG_SCLC	UBE2NL →	+0.126	+1.207	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048665 vs CLUAP1 — BLOOD_Lymphoma

Explore this scatter interactively →