Neuron fate commitment

Across TCGA cell cohorts, RNA activity of the Neuron fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HID1, ARL15, and HHLA3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron fate commitment activity versus HID1 in BLOOD_Lymphoma (Pearson r = 0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HID1 →	+1.750	+1.694	.003	.008	3	2
BLOOD_Lymphoma	ARL15 →	+2.325	+1.928	.003	.003	3	2
BLOOD_Lymphoma	HHLA3 →	+1.894	+1.928	.001	.003	3	2
BLOOD_Lymphoma	CHUK →	+1.025	+1.928	.004	.003	3	2
BLOOD_Leukemia	FSTL4 →	+0.080	+1.306	.003	.005	3	2
BREAST	EPHB3 →	+1.756	+1.603	.002	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048663 vs HID1 — BLOOD_Lymphoma

Explore this scatter interactively →