Negative regulation of smooth muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, PRKG1, and FLI1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell proliferation activity versus CNRIP1 in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNRIP1 →	+1.060	+0.221	<.001	<.001	3	9
UCEC	PRKG1 →	+0.971	+0.229	<.001	<.001	3	9
UCEC	FLI1 →	+0.600	+0.190	<.001	<.001	3	8
UCEC	NEXN →	+0.921	+0.176	.001	.002	3	8
UCEC	MSRB3 →	+1.037	+0.142	.001	.008	3	8
HNSC	MEF2C →	+0.898	+0.199	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048662 vs CNRIP1 — UCEC

Explore this scatter interactively →