Negative regulation of smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNC1H1, USH2A, and MSH5-SAPCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYNC1H1 grouped by Negative regulation of smooth muscle cell proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DYNC1H1 →	-0.352	-0.108	.003	.002	3	4
KIDNEY	USH2A →	-0.227	-0.117	<.001	.002	3	4
OVARY	MSH5-SAPCD1 →	-0.261	-0.101	.001	.007	3	4
KIDNEY	IER3 →	+0.386	+0.096	.005	.006	3	4
BLOOD_Leukemia	NELL2 →	-0.157	-0.117	<.001	<.001	3	4
SKIN	VPS13D →	-0.137	-0.071	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYNC1H1 by Negative regulation of smooth muscle cell proliferation activity — SKIN

Explore this box plot interactively →