Positive regulation of smooth muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, SPARC, and PAMR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell proliferation activity versus GJA1 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GJA1 →	+0.894	+0.251	<.001	<.001	3	4
CCRCC	SPARC →	+0.519	+0.216	.009	.001	3	3
CCRCC	PAMR1 →	+0.612	+0.217	.002	<.001	3	3
HNSC	NUP210 →	-0.905	-0.162	<.001	<.001	3	3
HNSC	EPS8 →	-0.791	-0.123	.002	.007	3	3
HNSC	ATP6V0E2 →	-0.692	-0.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048661 vs GJA1 — GBM

Explore this scatter interactively →