Positive regulation of smooth muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMF1, CGB7, and HSPE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell proliferation activity versus PMF1 in BONE (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PMF1 →	-0.867	-1.273	.009	.005	3	5
LUNG_NSCLC_LUAD	CGB7 →	+0.619	+0.799	.007	.003	1	6
BREAST	HSPE1 →	-0.894	-0.921	.001	.005	3	4
SKIN	MYEOV →	+2.314	+0.765	.001	.005	3	4
BREAST	NDUFV1 →	-0.436	-0.859	.009	.003	3	4
OESOPHAGUS	C1orf43 →	-0.678	-1.249	.009	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048661 vs PMF1 — BONE

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