Smooth muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Smooth muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPP1, THBD, and PECAM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle cell proliferation activity versus DEPP1 in OV (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DEPP1 →	+1.004	+0.166	.003	.005	3	5
OV	THBD →	+0.839	+0.132	<.001	.005	3	5
OV	PECAM1 →	+0.781	+0.169	.002	.001	3	5
PDAC	ZNF366 →	+0.306	+0.196	.001	<.001	3	5
COAD	CMAHP →	+0.476	+0.103	.007	.003	3	4
CCRCC	IL1RL1 →	+0.943	+0.138	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048659 vs DEPP1 — OV

Explore this scatter interactively →