Muscle organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Muscle organ morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN11, HSPG2, and APBB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle organ morphogenesis activity versus SEPTIN11 in OV (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEPTIN11 →	+0.429	+0.038	<.001	<.001	3	8
UCEC	HSPG2 →	+0.423	+0.036	.001	.003	3	8
PDAC	APBB2 →	+0.471	+0.047	<.001	<.001	3	8
UCEC	ARHGEF17 →	+0.347	+0.041	<.001	<.001	3	8
OV	EFEMP2 →	+0.740	+0.041	<.001	<.001	3	8
BRCA	NID1 →	+0.433	+0.027	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048644 vs SEPTIN11 — OV

Explore this scatter interactively →