Muscle organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Muscle organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAI2, NKAP, and TFPT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle organ morphogenesis activity versus RAI2 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAI2 →	+0.365	+0.299	.003	.004	3	4
OV	NKAP →	-0.559	-1.501	<.001	<.001	3	4
LSCC	TFPT →	-0.284	-0.887	.001	<.001	3	3
BRCA	SLC50A1 →	-0.479	-0.635	.002	.001	3	3
BRCA	COX14 →	-0.343	-0.671	.003	.002	3	3
BRCA	H2AJ →	-0.886	-0.570	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048644 vs RAI2 — GBM

Explore this scatter interactively →