Muscle organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Muscle organ morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSP, FMNL1_S184, and CAVIN2_S16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle organ morphogenesis activity versus DSP in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSP →	+0.469	+0.764	<.001	<.001	3	3
COAD	FMNL1_S184 →	-0.595	-0.407	<.001	.002	3	3
HNSC	CAVIN2_S16 →	+1.027	+0.952	<.001	.005	3	2
PDAC	ATN1_S739 →	-0.302	-0.613	<.001	.005	3	2
PDAC	ZNF263_S178 →	-0.605	-1.203	<.001	<.001	3	2
PDAC	DENND1A_S523 →	-0.765	-1.788	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048644 vs DSP — BRCA

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