Muscle organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Muscle organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDFIP2, LPAR5, and PKP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle organ morphogenesis activity versus NDFIP2 in LUNG_NSCLC_LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NDFIP2 →	+0.667	+0.656	.003	<.001	3	6
LUNG_NSCLC_LUAD	LPAR5 →	+1.617	+1.064	<.001	<.001	3	6
LUNG_SCLC	PKP2 →	+3.109	+1.091	<.001	.003	3	6
PANCREAS	CRYBG2 →	+2.428	+1.366	.003	.004	3	5
STOMACH	HIP1 →	-2.734	-0.396	.002	<.001	3	5
LUNG_NSCLC_LUAD	EPHA1 →	+1.838	+0.648	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048644 vs NDFIP2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →