Positive regulation of skeletal muscle tissue development

Across TCGA patient cohorts, RNA activity of the Positive regulation of skeletal muscle tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRHPR, DYNC1LI2_S194, and QDPR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of skeletal muscle tissue development activity versus GRHPR in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRHPR →	+0.306	+0.075	<.001	.002	3	7
LSCC	DYNC1LI2_S194 →	-0.356	-0.059	.001	.001	3	7
BRCA	QDPR →	+0.586	+0.039	<.001	<.001	3	7
BRCA	RSL1D1 →	-0.482	-0.051	<.001	<.001	3	7
BRCA	CNRIP1 →	+0.546	+0.054	<.001	<.001	3	7
BRCA	DDX18 →	-0.399	-0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048643 vs GRHPR — GBM

Explore this scatter interactively →