Positive regulation of skeletal muscle tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of skeletal muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC8C, PFDN5, and PPP1R18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC8C grouped by Positive regulation of skeletal muscle tissue development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LRRC8C →	-1.289	-0.207	.002	.003	3	5
PANCREAS	PFDN5 →	-0.543	-0.255	.004	<.001	3	4
PANCREAS	PPP1R18 →	-1.131	-0.209	.002	.001	3	4
PANCREAS	DNAJA1 →	-1.070	-0.252	<.001	<.001	3	4
LIVER	GCH1 →	+1.753	+0.201	.003	<.001	3	4
LUNG_NSCLC_LUSC	ST6GALNAC6 →	-1.128	-0.216	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC8C by Positive regulation of skeletal muscle tissue development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →