Negative regulation of developmental growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of developmental growth pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, MAP1B, and MAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of developmental growth activity versus SPP1 in HNSC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+2.039	+0.362	.001	.006	3	5
HNSC	MAP1B →	+1.233	+0.429	<.001	.002	3	5
LSCC	MAP2 →	+1.572	+0.769	<.001	<.001	3	5
LSCC	RHEB →	+0.565	+0.901	<.001	<.001	3	4
LSCC	MYOG →	+0.186	+0.737	.002	<.001	3	4
LSCC	SEMA4F →	+0.623	+0.687	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048640 vs SPP1 — HNSC

Explore this scatter interactively →