Positive regulation of developmental growth

Across TCGA patient cohorts, RNA activity of the Positive regulation of developmental growth pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, GHITM, and SMIM15-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of developmental growth activity versus MAP1B in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAP1B →	+1.334	+0.909	.002	<.001	3	3
BRCA	GHITM →	-0.348	-0.478	.004	.001	3	2
BRCA	SMIM15-AS1 →	+0.302	+0.359	<.001	.005	3	2
COAD	SGCA →	+0.469	+0.683	.009	.004	2	3
COAD	TPM1 →	+0.546	+0.949	.001	<.001	3	2
COAD	NEXN →	+0.687	+0.646	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048639 vs MAP1B — OV

Explore this scatter interactively →